Meso Scale Discovery (MSD)

Genemarkers offers Meso Scale Discovery (MSD) services to deliver highly sensitive, multiplexed measurements of protein biomarkers and other analytes in biological samples.

 How MSD WORKS

MSD testing utilizes electrochemiluminescence (ECL) to detect and quantify biomarkers. Target molecules in the sample are captured in a well plate, tagged with detection reagents, and then electrically stimulated. This reaction produces a light signal, which is measured to determine the presence and quantity of each biomarker.

 Why Choose MSD

MSD assays provide unmatched performance for biomarker analysis in drug development and clinical research. MSD is considered the gold standard of technologies to evaluate protein biomarkers in clinical research. 

 Taqman qPCR

Genemarkers offers TaqMan qPCR services for precise and quantitative measurement of gene expression in preclinical, translational, and clinical research. This technology is the gold standard for gene expression research and enables highly specific detection of DNA or RNA targets, supporting applications such as biomarker discovery, pharmacogenomics, and mechanistic studies.

 How Taqman qpCR WORKS

TaqMan qPCR uses fluorescently-labeled probes to detect and quantify nucleic acids in real-time. During amplification, the Taq polymerase enzyme cleaves the probe bound to the target sequence, releasing a fluorescent signal. The accumulation of fluorescence is directly proportional to the amount of target DNA or RNA in the sample, allowing for precise quantification across a broad dynamic range.

 Why Choose TAQman qpcr

TaqMan assays are a gold standard in molecular biology, known for their accuracy, reproducibility, and specificity. This technology is ideal for efficiently screening biological effects of compounds, and validating genomic biomarkers identified through sequencing studies to confirm observed gene expression changes.

 Illumina RNA-seq

Illumina RNA Sequencing (RNA Seq) is a cost-effective and high-throughput technology for differential gene expression, and is considered the gold standard in sequencing technology. By providing comprehensive insights of the entire transcriptome, RNA Seq enables researchers to evaluate quantitative gene expression data across biological systems in response to treatments. RNA Seq offers unmatched depth compared to other technologies, capturing both known and novel transcripts, alternative splice variants, single-nucleotide polymorphisms (SNPs), and more.

 How RNA-Seq WORKS

RNA is isolated, converted into cDNA, and sequenced to analyze gene expression. This process allows researchers to detect changes in gene expression and uncover mechanisms of action with high accuracy. The resulting data supports mechanistic studies, biomarker discovery, and validation. To support research and development, Genemarkers offers comprehensive RNA-seq services, including study design consultation and comprehensive bioinformatics support.

 why Choose RNA-Seq

Illumina RNA sequencing technology helps uncover biological mechanisms and key functional pathways, highlight novel biomarkers and targets of interest, and evaluate broad compound effects.